Report on the AAPM deep-learning spectral CT Grand Challenge.

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This Special Report summarizes the 2022 AAPM Grand Challenge on Deep-Learning spectral Computed Tomography (DL-spectral CT) image reconstruction.The purpose of the challenge is to develop the most accurate image reconstruction algorithm possible for solving the inverse problem associated with a fast kV switching dual-energy CT scan using a three tissue-map decomposition. Participants could choose to use a deep-learning (DL), iterative, or a hybrid approach.The challenge is based on a 2D breast CT simulation, where the simulated breast phantom consists of three tissue maps: adipose, fibroglandular, and calcification distributions. The phantom specification is stochastic so that multiple realizations can be generated for deep-learning approaches. A dual-energy scan is simulated where the X-ray source potential of successive views alternates between 50 and 80 kilovolts (kV). A total of 512 views are generated, yielding 256 views for each source voltage. We generate 50 and 80 kV images by use of filtered back-projection (FBP) on negative logarithm processed transmission data. For participants who develop a DL approach, 1000 cases are available. Each case consists of the three 512×512 tissue maps, 50 and 80 kV transmission data sets and their corresponding FBP images. The goal of the DL network would then be to predict the material maps from either the transmission data, FBP images, or a combination of the two. For participants developing a physics-based approach, all of the required modeling parameters are made available: geometry, spectra, and tissue attenuation curves. The provided information also allows for hybrid approaches where physics is exploited as well as information about the scanned object derived from the 1000 training cases. Final testing is performed by computation of root-mean-square-error (RMSE) for predictions on the tissue maps from 100 new cases.Test phase submission were received from 18 research groups. Of the 18 submissions, 17 were results obtained with algorithms that involved DL. Only the second place finishing team developed a physics-based image reconstruction algorithm. Both the winning and second place teams had highly accurate results where the RMSE was nearly zero to single floating point precision. Results from the top ten also achieved a high degree of accuracy; and as a result this special report outlines the methodology developed by each of these groups.The DL-spectral CT challenge successfully established a forum for developing image reconstruction algorithms that address an important inverse problem relevant for spectral CT.This article is protected by copyright. All rights reserved.