PRONTO-TK: a user-friendly PROtein Neural neTwOrk tool-kit for accessible protein function prediction.

Researchers

Journal

Modalities

Models

Abstract

Associating one or more Gene Ontology (GO) terms to a protein means making a statement about a particular functional characteristic of the protein. This association provides scientists with a snapshot of the biological context of the protein activity. This paper introduces PRONTO-TK, a Python-based software toolkit designed to democratize access to Neural-Network based complex protein function prediction workflows. PRONTO-TK is a user-friendly graphical interface (GUI) for empowering researchers, even those with minimal programming experience, to leverage state-of-the-art Deep Learning architectures for protein function annotation using GO terms. We demonstrate PRONTO-TK’s effectiveness on a running example, by showing how its intuitive configuration allows it to easily generate complex analyses while avoiding the complexities of building such a pipeline from scratch.© The Author(s) 2024. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.