Improved accuracy of relative electron density and proton stopping power ratio through CycleGAN machine learning.

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Abstract

Kilovoltage computed tomography (kVCT) is the cornerstone of radiotherapy treatment planning for delineating tissues and towards dose calculation. For the former, kVCT provides excellent contrast and signal-to-noise ratio. For the latter, kVCT may have greater uncertainty in determining relative electron density (ρ_e) and proton stopping power ratio (SPR). Conversely, megavoltage CT (MVCT) may result in superior dose calculation accuracy. The purpose of this work was to convert kVCT HU to MVCT HU using deep learning to obtain higher accuracy ρ_e and SPR.Tissue-mimicking phantoms were created to compare kVCT- and MVCT-determined ρ_e and SPR to physical measurements. Using 100 head-and-neck datasets, an unpaired deep learning model was trained to learn the relationship between kVCTs and MVCTs, creating synthetic MVCTs (sMVCTs). Similarity metrics were calculated between kVCTs, sMVCTs, and MVCTs in 20 test datasets. An anthropomorphic head phantom containing bone-mimicking material with known composition was scanned to provide an independent determination of ρ_e and SPR accuracy by sMVCT.In tissue-mimicking bone, ρ_e errors were 2.20% versus 0.19% and SPR errors were 4.38% versus 0.22%, for kVCT versus MVCT, respectively. Compared to MVCT, in vivo mean difference (MD) values were 11 and 327 HU for kVCT and 2 and 3 HU for sMVCT in soft tissue and bone, respectively. ρ_e MD decreased from 1.3% to 0.35% in soft tissue and 2.9% to 0.13% in bone, for kVCT and sMVCT, respectively. SPR MD decreased from 1.8% to 0.24% in soft tissue and 6.8% to 0.16% in bone, for kVCT and sMVCT, respectively. Relative to physical measurements, ρ_e and SPR error in anthropomorphic bone decreased from 7.50% and 7.48% for kVCT to <1% for both MVCT and sMVCT.Deep learning can be used to map kVCT to sMVCT, suggesting higher accuracy ρ_e and SPR is achievable with sMVCT versus kVCT.© 2022 Institute of Physics and Engineering in Medicine.