Fully automatic volume segmentation using deep learning approaches to assess aneurysmal sac evolution after infra-renal endovascular aortic repair.

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Abstract

Endovascular aortic repair (EVAR) surveillance relies on serial measurements of maximal diameter despite significant inter- and intra-observer variability. Volumetric measurements are more sensitive but general use is hampered by the time required for their implementation. An innovative fully automated software (PRAEVAorta® from Nurea), using artificial intelligence (AI), previously demonstrated fast and robust detection of infra-renal abdominal aortic aneurysm’s (AAA) characteristics on pre-operative imaging. This study aimed to assess the robustness of these data on post-EVAR computed tomography (CT) scans.Comparison was made between fully automatic and semi-automatic segmentation manually corrected by a senior surgeon on a dataset of 48 patients (48 early post-EVAR CT scans with 6466 slices, and a total of 101 follow-up CT scans with 13708 slices).The analyses confirmed an excellent correlation of post-EVAR volumes and surfaces, as well as, proximal neck and maximum aneurysm diameters measured with the fully automatic and manually corrected segmentation methods (Pearson’s coefficient correlation >.99, p<.0001). Comparison between the fully automatic and manually corrected segmentation method revealed a mean Dice Similarity Coefficient of 0.950±0.015, Jaccard index of 0.906±0.028, Sensitivity of 0.929±0.028, Specificity of 0.965±0.016, Volumetric Similarity (VS) of 0.973±0.018 and mean Hausdorff Distance/slice of 8.7±10.8mm. The mean VS reached 0.873±0.100 for the lumen and 0.903±0.091 for the thrombus. The segmentation time was 9 times faster with the fully automatic method (2.5 vs 22 min/patient with the manually corrected method; p<.0001). Preliminary analysis also demonstrated that a diameter increase of 2mm can actually represent >5% volume increase.PRAEVAorta® enables a fast, reproducible, and fully automated analysis of post-EVAR AAA sac and neck characteristics, with comparison between different time points. It could become a crucial adjunct for EVAR follow-up through early detection of sac evolution, which may reduce the risk of secondary rupture.Copyright © 2022. Published by Elsevier Inc.