Deep Learning Segmentation of Ascites on Abdominal CT Scans for Automatic Volume Quantification.
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Abstract
“Just Accepted” papers have undergone full peer review and have been accepted for publication in Radiology: Artificial Intelligence. This article will undergo copyediting, layout, and proof review before it is published in its final version. Please note that during production of the final copyedited article, errors may be discovered which could affect the content. Purpose To evaluate the performance of an automated deep learning method in detecting ascites and subsequently quantifying its volume in patients with liver cirrhosis and ovarian cancer. Materials and Methods This retrospective study included contrast-enhanced and noncontrast abdominal-pelvic CT scans of patients with cirrhotic ascites and patients with ovarian cancer from two institutions, National Institutes of Health (NIH) and University of Wisconsin (UofW). The model, trained on The Cancer Genome Atlas Ovarian Cancer dataset (mean age, 60 years ± 11 [SD]; 143 female), was tested on two internal (NIH-LC and NIH-OV) and one external dataset (UofW-LC). Its performance was measured by the Dice coefficient, standard deviations, and 95% confidence intervals, focusing on ascites volume in the peritoneal cavity. Results On NIH-LC (25 patients; mean age, 59 years ± 14; 14 male) and NIH-OV (166 patients; mean age, 65 years ± 9; all female), the model achieved Dice scores of 85.5% ± 6.1% (CI: 83.1%-87.8%) and 82.6% ± 15.3% (CI: 76.4%-88.7%), with median volume estimation errors of 19.6% (IQR: 13.2%-29.0%) and 5.3% (IQR: 2.4%- 9.7%), respectively. On UofW-LC (124 patients; mean age, 46 years ± 12; 73 female), the model had a Dice score of 83.0% ± 10.7% (CI: 79.8%-86.3%) and median volume estimation error of 9.7% (IQR: 4.5%-15.1%). The model showed strong agreement with expert assessments, with r2 values of 0.79, 0.98, and 0.97 across the test sets. Conclusion The proposed deep learning method performed well in segmenting and quantifying the volume of ascites in concordance with expert radiologist assessments. ©RSNA, 2024.