Comparison between renal pelvic and ureteral tumors in muscle-invasive upper tract urothelial carcinoma.

Researchers

Journal

Modalities

Models

Abstract

While renal pelvic and ureteral urothelial carcinoma shared similarities in the origin, disparities on a genetic and clinical level make them divergent entities. Clinical information from SEER database were used to validate the characteristics and molecular subtypes using single-center data were compared between two muscle-invasive tumors. Simultaneously, to expand the sample size for further verification, we explored a deep learning algorithm to correctly classify two tumor’s molecular subtype from hematoxylin and eosin (H&E) histology slides. We suggested that the renal pelvic group might have a proclivity towards luminal and the ureter towards basal and P53-like. Furthermore, we explore the heterogeneity of matrix and immune tumor microenvironment, and ureteral group had more immune cell infiltration and higher stiffness. Collectively, these results showed that muscle-invasive UTUC exist in distinct properties of clinical characteristics, molecular subtype, and tumor microenvironment.This article is protected by copyright. All rights reserved.