Classification of Pap-smear cell images using deep convolutional neural network accelerated by hand-crafted features.

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Abstract

The classification of cells extracted from Pap-smears is in most cases done using neural network architectures. Nevertheless, the importance of features extracted with digital image processing is also discussed in many related articles. Decision support systems and automated analysis tools of Pap-smears often use these kinds of manually extracted, global features based on clinical expert opinion. In this paper, a solution is introduced where 29 different contextual features are combined with local features learned by a neural network so that it increases classification performance. The weight distribution between the features is also investigated leading to a conclusion that the numerical features are indeed forming an important part of the learning process. Furthermore, extensive testing of the presented methods is done using a dataset annotated by clinical experts. An increase of 3.2% in F1-Score value can be observed when using the combination of contextual and local features. Clinical Relevance – Analysis of images extracted from digital Pap-test using modern machine learning tools is discussed in many scientific papers. The manual classification of the cells can be time-consuming and expensive which requires a high amount of manual labor. Furthermore the result of the manual classification can also be uncertain due to interobserver variability. Considering these, any result that can lead to a more reliable highly accurate classification method is considered valuable in the field of cervical cancer screening.