Artificial Intelligence Model Assisting Thyroid Nodule Diagnosis and Management: A Multicenter Diagnostic Study.

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To develop and validate a deep-learning-based AI model (AI-Thyroid) for thyroid cancer diagnosis, and to explore how this improve diagnostic performance.The system was trained using 19,711 images of 6,163 patients in a tertiary hospital. It was validated using 11,185 images of 4,820 patients in 24 hospitals (test set 1) and 4,490 images of 2,367 patients in ____ (test set 2). The clinical implications were determined by comparing the findings of six physicians with different levels of experience (group 1: four trainees, and group 2: two faculty radiologists) before and after AI-Thyroid assistance.The area under the receiver operating characteristic (AUROC) curve of AI-Thyroid was 0.939. The AUROC, sensitivity, and specificity were 0.922, 87.0%, and 81.5% for test set 1 and 0.938, 89.9%, and 81.6% for test set 2. The AUROCs of AI-Thyroid did not differ significantly according to the prevalence of malignancies (> 15.0% vs. ≤ 15.0%, p = 0.226). In the simulated scenario, AI-Thyroid assistance changed the AUROC, sensitivity, and specificity from 0.854 to 0.945, from 84.2% to 92.7%, and from 72.9% to 86.6% (all p < 0.001) in group 1, and from 0.914 to 0.939 (p = 0.022), from 78.6% to 85.5% (p = 0.053) and from 91.9% to 92.5% (p = 0.683) in group 2. The interobserver agreement improved from moderate to substantial in both groups.AI-Thyroid can improve diagnostic performance and interobserver agreement in thyroid cancer diagnosis, especially in less-experienced physicians.© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected].