AMPFinder: A computational model to identify antimicrobial peptides and their functions based on sequence-derived information.

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Abstract

Antimicrobial peptides (AMPs) called host defense peptides have existed among all classes of life with 5-100 amino acids generally and can kill mycobacteria, envelop viruses, bacteria, fungi, cancerous cells and so on. Owing to the non-drug resistance of AMP, it has been a wonderful agent to find novel therapies. Therefore, it is urgent to identify AMPs and predict their function in a high-throughput way. In this paper, we propose a cascaded computational model to identify AMPs and their functional type based on sequence-derived and life language embedding, called AMPFinder. Compared with other state-of-the-art methods, AMPFinder obtains higher performance both on AMP identification and AMP function prediction. AMPFinder shows better performance with improvement of F1-score (1.45%-6.13%), MCC (2.92%-12.86%) and AUC (5.13%-8.56%) and AP (9.20%-21.07%) on an independent test dataset. And AMPFinder achieve lower bias of R2 on a public dataset by 10-fold cross-validation with an improvement of (18.82%-19.46%). The comparison with other state-of-the-art methods shows that AMP can accurately identify AMP and its function types. The datasets, source code and user-friendly application are available at https://github.com/abcair/AMPFinder.Copyright © 2023. Published by Elsevier Inc.