A Novel Drug Repositioning Approach Based on Integrative Multiple Similarity Measures.

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Abstract

Drug repositioning refers to discovering new indications for the existing drugs, which can improve the efficiency of drug research and development.
In this work, a novel drug repositioning approach based on integrative multiple similarity measure, called DR_IMSM, is proposed. The process of integrative similarity measure contains three steps. First, a heterogeneous network can be constructed based on known drug-disease association, shared entities information for drug pairwise and diseases pairwise. Second, a deep learning method, DeepWalk, is used to capture the topology similarity for drug and disease. Third, a similarity integration and adjusting process are further conducted to obtain more comprehensive drug and disease similarity measure,respectively.
On this basis, an Bi-random walk algorithm is implemented in the constructed heterogeneous network to rank diseases for each drug. Compared with other approaches, the proposed DR_IMSM can achieve superior performance in terms of AUC on the gold standard datasets. Case studies further confirm the practical significance of DR_IMSM.
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