Weakly Supervised Breast Lesion Detection in DCE-MRI using Self-Transfer Learning.

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Abstract

Breast cancer is a typically diagnosed and life-threatening cancer in women. Thus, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is increasingly used for breast lesion detection and diagnosis because of the high resolution of soft tissues. Moreover, supervised detection methods have been implemented for breast lesion detection. However, these methods require substantial time and specialized staff to develop the labeled training samples.To investigate the potential of weakly supervised deep learning models for breast lesion detection.A total of 1003 breast DCE-MRI studies were collected, including 603 abnormal cases with 770 breast lesions and 400 normal subjects. The proposed model was trained using breast DCE-MRI considering only the image-level labels (normal and abnormal) and optimized for classification and detection sub-tasks simultaneously. Ablation experiments were performed to evaluate different convolutional neural network (CNN) backbones (VGG19 and ResNet50) as shared convolutional layers, as well as to evaluate the effect of the preprocessing methods.Our weakly supervised model performed better with VGG19 than with ResNet50 (P < 0.05). The average precision (AP) of the classification sub-task was 91.7% for abnormal cases and 88.0% for normal samples. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.939 (95% confidence interval [CI]:0.920-0.941). The weakly supervised detection task AP was 85.7%, and the correct location (CorLoc) was 90.2%. A sensitivity of 84.0% at two-false positives per image was assessed based on free-response ROC (FROC) curve.The results confirm that a weakly supervised CNN based on self-transfer learning is an effective and promising auxiliary tool for detecting breast lesions. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.