Visual Field Inference From Optical Coherence Tomography Using Deep Learning Algorithms: A Comparison Between Devices.

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Abstract

To develop a deep learning model to estimate the visual field (VF) from spectral-domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT) and to compare the performance between them.
Two deep learning models based on Inception-ResNet-v2 were trained to estimate 24-2 VF from SS-OCT and SD-OCT images. The estimation performance of the two models was evaluated by using the root mean square error between the actual and estimated VF. The performance was also compared among different glaucoma severities, Garway-Heath sectorizations, and central/peripheral regions.
The training dataset comprised images of 4391 eyes from 2350 subjects, and the test dataset was obtained from another 243 subjects (243 eyes). In all subjects, the global estimation errors were 5.29 ± 2.68 dB (SD-OCT) and 4.51 ± 2.54 dB (SS-OCT), and the estimation error of SS-OCT was significantly lower than that of SD-OCT (P < 0.001). In the analysis of sectors, SS-OCT showed better performance in all sectors except for the inferonasal sector in normal vision and early glaucoma. In advanced glaucoma, the estimation error of the central region was worsened in both OCTs, but SS-OCT was still significantly better in the peripheral region.
Our deep learning model estimated the VF 24-2 better with a wide field image of SS-OCT than did with retinal nerve fiber layer and ganglion cell-inner plexiform layer images of SD-OCT.
This deep learning method can help clinicians to determine the VF from OCT images. OCT manufacturers can equip this system to provide additional VF data.