Video-Based Deep Learning for Automated Assessment of Left Ventricular Ejection Fraction in Pediatric Patients.

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Abstract

Significant interobserver and interstudy variability occurs for left ventricular functional indices despite standardization of measurement techniques. Artificial intelligence models trained on adult echocardiograms are not likely to be applicable to a pediatric population. We present EchoNet-Peds, a video-based deep learning algorithm, which matches human expert performance of left ventricular (LV) segmentation and ejection fraction (EF).A large pediatric dataset of 4,467 echocardiograms were used to develop EchoNet-Peds. EchoNet-Peds was trained on 80% of the data for segmentation of the left ventricle and estimation of left ventricular EF. The remaining 20% was used to fine tune and validate the algorithm.In both apical 4-chamber (A4C) and parasternal short-axis views (PSAX), EchoNet-Peds segments the left ventricle with a Dice similarity coefficient of 0.89. EchoNet-Peds estimates EF with a mean absolute error of 3.66% and can routinely identify pediatric patients with systolic dysfunction (area under the curve of 0.95). EchoNet-Peds was trained on pediatric echocardiograms and performed significantly better to estimate EF (p < 0.001) than an adult model applied to the same data.Accurate, rapid automation of EF assessment and recognition of systolic dysfunction in a pediatric population are feasible using EchoNet-Peds with the potential for far-reaching clinical impact. In addition, the first large pediatric dataset of annotated echocardiograms is now publicly available for efforts to develop pediatric-specific artificial intelligence algorithms.Copyright © 2023 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.