VASARI-auto: Equitable, efficient, and economical featurisation of glioma MRI.

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Abstract

The VASARI MRI feature set is a quantitative system designed to standardise glioma imaging descriptions. Though effective, deriving VASARI is time-consuming and seldom used clinically. We sought to resolve this problem with software automation and machine learning. Using glioma data from 1172 patients, we developed VASARI-auto, an automated labelling software applied to open-source lesion masks and an openly available tumour segmentation model. Consultant neuroradiologists independently quantified VASARI features in 100 held-out glioblastoma cases. We quantified 1) agreement across neuroradiologists and VASARI-auto, 2) software equity, 3) an economic workforce analysis, and 4) fidelity in predicting survival. Tumour segmentation was compatible with the current state of the art and equally performant regardless of age or sex. A modest inter-rater variability between in-house neuroradiologists was comparable to between neuroradiologists and VASARI-auto, with far higher agreement between VASARI-auto methods. The time for neuroradiologists to derive VASARI was substantially higher than VASARI-auto (mean time per case 317 vs. 3 s). A UK hospital workforce analysis forecast that three years of VASARI featurisation would demand 29,777 consultant neuroradiologist workforce hours and >£1.5 ($1.9) million, reducible to 332 hours of computing time (and £146 of power) with VASARI-auto. The best-performing survival model utilised VASARI-auto features instead of those derived by neuroradiologists. VASARI-auto is a highly efficient and equitable automated labelling system, a favourable economic profile if used as a decision support tool, and non-inferior survival prediction. Future work should iterate upon and integrate such tools to enhance patient care.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.