Utility of deep learning super-resolution in the context of osteoarthritis MRI biomarkers.
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Abstract
Super-resolution is an emerging method for enhancing MRI resolution; however, its impact on image quality is still unknown.
To evaluate MRI super-resolution using quantitative and qualitative metrics of cartilage morphometry, osteophyte detection, and global image blurring.
Retrospective.
In all, 176 MRI studies of subjects at varying stages of osteoarthritis.
Original-resolution 3D double-echo steady-state (DESS) and DESS with 3Γ thicker slices retrospectively enhanced using super-resolution and tricubic interpolation (TCI) at 3T.
A quantitative comparison of femoral cartilage morphometry was performed for the original-resolution DESS, the super-resolution, and the TCI scans in 17 subjects. A reader study by three musculoskeletal radiologists assessed cartilage image quality, overall image sharpness, and osteophytes incidence in all three sets of scans. A referenceless blurring metric evaluated blurring in all three image dimensions for the three sets of scans.
Mann-Whitney U-tests compared Dice coefficients (DC) of segmentation accuracy for the DESS, super-resolution, and TCI images, along with the image quality readings and blurring metrics. Sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence intervals compared osteophyte detection for the super-resolution and TCI images, with the original-resolution as a reference.
DC for the original-resolution (90.2βΒ±β1.7%) and super-resolution (89.6βΒ±β2.0%) were significantly higher (Pβ<β0.001) than TCI (86.3βΒ±β5.6%). Segmentation overlap of super-resolution with the original-resolution (DC = 97.6βΒ±β0.7%) was significantly higher (Pβ<β0.0001) than TCI overlap (DC = 95.0βΒ±β1.1%). Cartilage image quality for sharpness and contrast levels, and the through-plane quantitative blur factor for super-resolution images, was significantly (Pβ<β0.001) better than TCI. Super-resolution osteophyte detection sensitivity of 80% (76-82%), specificity of 93% (92-94%), and DOR of 32 (22-46) was significantly higher (Pβ<β0.001) than TCI sensitivity of 73% (69-76%), specificity of 90% (89-91%), and DOR of 17 (13-22).
Super-resolution appears to consistently outperform naΓ―ve interpolation and may improve image quality without biasing quantitative biomarkers.
2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019.
Β© 2019 International Society for Magnetic Resonance in Medicine.