The development of “Automated Visual Evaluation” for cervical cancer screening: The promise and challenges in adapting deep-learning for clinical testing.

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Abstract

There is limited access to effective cervical cancer screening programs in many resource-limited settings, resulting in continued high cervical cancer burden. HPV testing is increasingly recognized to be the preferable primary screening approach if affordable due to superior long-term reassurance when negative and adaptability to self-sampling. Visual inspection with acetic acid (VIA) is an inexpensive but subjective and inaccurate method widely used in resource-limited settings, either for primary screening or for triage of HPV-positive individuals. A deep learning (DL)-based automated visual evaluation (AVE) of cervical images has been developed to help improve the accuracy and reproducibility of VIA as assistive technology. However, like any new clinical technology, rigorous evaluation and proof of clinical effectiveness are required before AVE is implemented widely. In the current paper, we outline essential clinical and technical considerations involved in building a validated DL-based AVE tool for broad use as a clinical test.This article is protected by copyright. All rights reserved.