Robust and Effective: A Deep Matrix Factorization Framework for Classification.

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Abstract

For complex data, high dimension and high noise are challenging problems, and deep matrix factorization shows great potential in data dimensionality reduction. In this article, a novel robust and effective deep matrix factorization framework is proposed. This method constructs a dual-angle feature for single-modal gene data to improve the effectiveness and robustness, which can solve the problem of high-dimensional tumor classification. The proposed framework consists of three parts, deep matrix factorization, double-angle decomposition, and feature purification. First, a robust deep matrix factorization (RDMF) model is proposed in the feature learning, to enhance the classification stability and obtain better feature when faced with noisy data. Second, a double-angle feature (RDMF-DA) is designed by cascading the RDMF features with sparse features, which contains the more comprehensive information in gene data. Third, to avoid the influence of redundant genes on the representation ability, a gene selection method is proposed to purify the features by RDMF-DA, based on the principle of sparse representation (SR) and gene coexpression. Finally, the proposed algorithm is applied to the gene expression profiling datasets, and the performance of the algorithm is fully verified.