Multiparametric Deep Learning Tissue Signatures for a Radiological Biomarker of Breast Cancer: Preliminary Results.

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Abstract

Deep learning is emerging in radiology due the increased computational capabilities available to reading rooms. These computational developments have the ability to mimic the radiologist may allow for more accurate tissue characterization of normal and pathological lesion tissue to assist radiologists in defining different diseases. We introduce a novel tissue signature model based on tissue characteristics in breast tissue from multiparametric magnetic resonance imaging (mpMRI). The breast tissue signatures are used as inputs a stacked sparse autoencoder (SSAE) multiparametric deep learning (MPDL) network for segmentation of breast mpMRI.
We constructed the MPDL network from SSAE with five layers with 10 nodes at each layer. A total cohort of 195 breast cancer subjects were used for training and testing of the MPDL network. The cohort consisted of a training data set of 145 subjects and an independent validation set of 50 subjects. After segmentation, we used a combined SAE-Support Vector Machine (SAE-SVM) learning method for classification. Dice similarity (DS) metrics were calculated between the segmented MPDL and Dynamic Contrast Enhancement (DCE) MRI defined lesions. Sensitivity, specificity, and Area Under the Curve (AUC) metrics were used to classify benign from malignant lesions.
The MPDL segmentation resulted in a high DS of 0.87±0.05 for malignant lesions and 0.84±0.07 for benign lesions. The MPDL had excellent sensitivity and specificity of 86% and 86% with positive predictive and negative predictive values of 92% and 73% respectively and an AUC of 0.90.
Using a new tissue signature model as inputs into the MPDL algorithm, we have successfully validated MPDL in a large cohort of subjects and achieved results similar to radiologists.
© 2019 American Association of Physicists in Medicine.