Inconsistent Performance of Deep Learning Models on Mammogram Classification.

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Abstract

Performance of recently developed deep learning models for image classification surpasses that of radiologists. However, there are questions about model performance consistency and generalization in unseen external data. The purpose of this study is to determine if the high performance of deep learning on mammograms can be transferred to external data with a different data distribution.
Six deep learning models (three published models with high performance and three models designed by us) were evaluated on four different mammogram data sets, including three public (Digital Database for Screening Mammography, INbreast, and Mammographic Image Analysis Society) and one private data set (UKy). The models were trained and validated on either Digital Database for Screening Mammography alone or a combined data set that included Digital Database for Screening Mammography. The models were then tested on the three external data sets. The area under the receiver operating characteristic curve was used to evaluate model performance.
The three published models reported validation area under the receiver operating characteristic curve scores between 0.88 and 0.95 on the validation data set. Our models achieved between 0.71 (95% confidence interval [CI]: 0.70-0.72) and 0.79 (95% CI: 0.78-0.80) area under the receiver operating characteristic curve on the same validation data set. However, the same evaluation criteria of all six models on the three external test data sets were significantly decreased, only between 0.44 (95% CI: 0.43-0.45) and 0.65 (95% CI: 0.64-0.66).
Our results demonstrate performance inconsistency across the data sets and models, indicating that the high performance of deep learning models on one data set cannot be readily transferred to unseen external data sets, and these models need further assessment and validation before being applied in clinical practice.
Copyright © 2020 American College of Radiology. Published by Elsevier Inc. All rights reserved.