Fundus images analysis using deep features for detection of exudates, hemorrhages and microaneurysms.

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Abstract

Convolution neural networks have been considered for automatic analysis of fundus images to detect signs of diabetic retinopathy but suffer from low sensitivity.
This study has proposed an alternate method using probabilistic output from Convolution neural network to automatically and simultaneously detect exudates, hemorrhages and microaneurysms. The method was evaluated using two approaches: patch and image-based analysis of the fundus images on two public databases: DIARETDB1 and e-Ophtha. The novelty of the proposed method is that the images were analyzed using probability maps generated by score values of the softmax layer instead of the use of the binary output.
The sensitivity of the proposed approach was 0.96, 0.84 and 0.85 for detection of exudates, hemorrhages and microaneurysms, respectively when considering patch-based analysis. The results show overall accuracy for DIARETDB1 was 97.3% and 86.6% for e-Ophtha. The error rate for image-based analysis was also significantly reduced when compared with other works.
The proposed method provides the framework for convolution neural network-based analysis of fundus images to identify exudates, hemorrhages, and microaneurysms. It obtained accuracy and sensitivity which were significantly better than the reported studies and makes it suitable for automatic diabetic retinopathy signs detection.