Dyskinesia Estimation of Imbalanced Data Using a Deep-Learning Model.

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Abstract

The collection of Parkinson’s Disease (PD) time-series data usually results in imbalanced and incomplete datasets due to the geometric distribution of PD complications’ sever-ity scores. Consequently, when training deep convolutional models on these datasets, the models suffer from overfitting and lack generalizability to unseen data. In this paper, we investigated a new framework of Conditional Generative Ad-versarial Netuwoks (cGANs) as a solution to improve the extrapolation and generalizability of the regression models in such datasets. We used a real-world PD dataset to esti-mate Dyskinesia severity in patients with PD. The developed cGAN demonstrated significantly better generalizability to unseen data samples than a traditional Convolutional Neural Network with an improvement of 34%. This solution can be applied in similar imbalanced time-series data, especially in the healthcare domain, where balanced and uniformly distributed data samples are not readily available.