DeepGA for automatically estimating fetal gestational age through ultrasound imaging.

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Abstract

Accurate estimation of gestational age (GA) is vital for identifying fetal abnormalities. Conventionally, GA is estimated by measuring the morphology of the cranium, abdomen, and femur manually and inputting them into the classic Hadlock formula to assess fetal growth. However, this procedure incurs considerable overhead and suffers from bias caused by the operators, yielding suboptimal estimations. To address this challenge, we develop an automatic DeepGA model to achieve fully automatic GA prediction in an end-to-end manner. Our model uses a deep segmentation model (DeepSeg) to accurately identify and segment three critical tissues, including the cranium, abdomen, and femur, in which their morphology is automatically extracted. After that, we are able to directly estimate the GA via a deep regression model (DeepReg). We evaluate DeepGA on a large dataset, including 10,413 ultrasound images from 7113 subjects. It achieves superior performance over the traditional measurement approach, with a mean absolute estimation error (MAE) of 5 days. Our DeepGA model is a novel automatic solution on the basis of artificial intelligence learning that can help radiologists improve the performance of GA estimation in various clinical scenarios, thereby enhancing the efficiency of prenatal examinations.Copyright © 2022 Elsevier B.V. All rights reserved.