DeepBCE: Evaluation of deep learning models for identification of immunogenic B-cell epitopes.

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Abstract

B-Cell epitopes (BCEs) can identify and bind with receptor proteins (antigens) to initiate an immune response against pathogens. Understanding antigen-antibody binding interactions has many applications in biotechnology and biomedicine, including designing antibodies, therapeutics, and vaccines. Lab-based experimental identification of these proteins is time-consuming and challenging. Computational techniques have been proposed to discover BCEs, but most lack of significant accomplishments. This work uses classical and deep learning models (DLMs) with sequence-based features to predict immunity stimulator BCEs from proteomics sequences. The proposed convolutional neural network-based model outperforms other models with an accuracy (ACC) of 0.878, an F-measure of 0.871, and an area under the receiver operating characteristic curve (AUC) of 0.945. The proposed strategy achieves 58.7% better results on average than other state-of-the-art approaches based on the Mathews Correlation Coefficient (MCC) results. The established model is accessible through a web application located at http://deeplbcepred.pythonanywhere.com.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.