Deep Learning-based Diagnosis of Glaucoma Using Wide-field Optical Coherence Tomography Images.

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Abstract

(1) To evaluate the performance of a deep learning (DL) classifier in detecting glaucoma, based on wide-field swept-source optical coherence tomography (SS-OCT) images. (2) To assess the performance of DL-based fusion methods in diagnosing glaucoma using a variety of wide-field SS-OCT images and compare their diagnostic abilities with that of conventional parameter-based methods.
Overall, 675 eyes, including 258 healthy eyes and 417 eyes with glaucoma were enrolled in this retrospective observational study. Each single-page wide-field report (12×9 mm) of wide-field SS-OCT imaging provides different types of images that reflect the state of the eyes. A DL-based automated diagnosis system was proposed to detect glaucoma and identify its stage based on such images. We applied the convolutional neural network (CNN) to each type of image to detect glaucoma. Additinally, two fusion strategies, fusion by convolution network (FCN) and fusion by fully-connected network (FFC) were developed; they differ in terms of the level of fusion of features derived from CNNs. The diagnostic models were trained using 382 and 293 images in the training and test datasets, respectively. The diagnostic ability of this method was compared with conventional parameters of thickness of retinal nerve fiber layer and ganglion cell complex.
FCN achieved area under the receiver operating characteristic curve (AUC) of 0.987 (95% confidence interval, CI: 0.968-0.996) and accuracy of 95.22%. In contrast, FFC achieved AUC of 0.987 (95%CI, 0.971-0.998) and accuracy of 95.90%. Both FCN and FFC outperformed the conventional method (P<0.001). In detecting early glaucoma, both FCN and FFC achieved significantly higher AUC and accuracy than the conventional approach (P<0.001). Additionally, the classification performance of the DL-based fusion methods in identifying the five stages of glaucoma is presented via a confusion matrix.
DL protocol based on wide-field OCT images outperformed the conventional method in terms of both AUC and accuracy. Therefore, DL-based diagnostic methods using wide-field OCT images are promising in diagnosing glaucoma in clinical practice.
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