AML leukocyte classification method for small samples based on ACGAN.

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Abstract

Leukemia is a class of hematologic malignancies, of which acute myeloid leukemia (AML) is the most common. Screening and diagnosis of AML are performed by microscopic examination or chemical testing of images of the patient’s peripheral blood smear. In smear-microscopy, the ability to quickly identify, count, and differentiate different types of blood cells is critical for disease diagnosis. With the development of deep learning (DL), classification techniques based on neural networks have been applied to the recognition of blood cells. However, DL methods have high requirements for the number of valid datasets. This study aims to assess the applicability of the auxiliary classification generative adversarial network (ACGAN) in the classification task for small samples of white blood cells. The method is trained on the TCIA dataset, and the classification accuracy is compared with two classical classifiers and the current state-of-the-art methods. The results are evaluated using accuracy, precision, recall, and F1 score. The accuracy of the ACGAN on the validation set is 97.1 % and the precision, recall, and F1 scores on the validation set are 97.5 , 97.3, and 97.4 %, respectively. In addition, ACGAN received a higher score in comparison with other advanced methods, which can indicate that it is competitive in classification accuracy.© 2024 Walter de Gruyter GmbH, Berlin/Boston.