Artificial intelligence as a smart approach to develop antimicrobial drug molecules: a paradigm to combat drug-resistant infections.

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Abstract

Antimicrobial resistance (AMR) is a silent pandemic with the third highest global mortality. The antibiotic development pipeline is scarce even though AMR has escalated uncontrollably. Artificial intelligence (AI) is a revolutionary approach, accelerating drug discovery because of its fast pace, cost efficiency, lower labor requirements, and fewer chances of failure. AI has been used to discover several beta-lactamase inhibitors and antibiotic alternatives from antimicrobial peptides (AMPs), nonribosomal peptides, bacteriocins, and marine natural products. The significant recent increase in the use of AI platforms by pharmaceutical companies could result in the discovery of efficient antibiotic alternatives with lower chances of resistance generation. Teaser: Antimicrobial resistance is a global threat but the antibiotic pipeline is dry. Artificial intelligence is revolutionizing drug discovery and finding antibiotic alternatives with least-resistance probability, minimum cost, time, and labor.Copyright © 2023. Published by Elsevier Ltd.